منابع مشابه
Catalytic enantioselective Reformatsky reaction with ketones.
Chiral tertiary alcohols were obtained with good yields and enantioselectivities via a catalytic Reformatsky reaction with ketones, including the challenging diaryl ketones, using chiral BINOL derivatives.
متن کاملRecent developments in the asymmetric Reformatsky-type reaction
This review collects the most important developments in asymmetric Reformatsky-type reactions published since the beginning of 2013, including both diastereoselective methodologies based on the use of chiral substrates and enantioselective catalytic procedures.
متن کاملDouble Reformatsky reaction: divergent synthesis of δ-hydroxy-β-ketoesters.
The double Reformatsky reaction, tandem addition of two molecules of zinc alkanoate to a carbonyl compound, and its synthetic application to a series of δ-hydroxy-β-ketoesters has been developed. The key to accelerate the double Reformatsky reaction is considered to be a complex-induced proximity effect of the in situ generated zinc alkoxide coordinated with the pyridyl group of the substrate o...
متن کاملFirst enantioselective one-pot, three-component imino Reformatsky reaction*
The Reformatsky reaction is the well-recognized carbon–carbon bond-forming reaction of α-halo esters with aldehydes or ketones in the presence of Zn metal to give β-hydroxy esters. Recently, it has been reported that Rhand Ni-catalyzed Reformatsky reaction, in which R2Zn (R = Me, Et) acts as the Zn source, reacted smoothly with carbonyl compounds and imines. Taking advantage of N-methylephedrin...
متن کاملAn improved asymmetric reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol.
[reaction: see text] (-)-N,N-Dimethylaminoisoborneol ((-)-DAIB) was found to be an excellent ligand for the enantioselective addition of Reformatsky reagents to aromatic and aliphatic aldehydes. Enantioselectivities up to 93% ee were obtained with sulfur-containing aldehydes.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1973
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.93.9_1234